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64196

IMIDAZOLE ALKALOIDS FROM THE INDOPACIFIC SPONGE PERICHARAX HETERORAPHIS

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Last updated: 04 Jan 2025

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Abstract

Chemical investigation of the sponge Pericharax heteroraphis (Polejeff) collected in Indonesia, has led to the isolation of three imidazole alkaloids, preclathridine-A (1), leucettamine-B (2) and leucettamine-A (3). The structures of the isolated compounds were unambiguously established by 1D and 2D NMR and mass data. This is the first report of this class of compounds from the P. heteroraphis sponge. Investigation of the antimicrobial activities of the isolated compounds showed that leucettamin-A (3) was active against the gram-positive bacteria Staphylococcus aureus and the fungus Cladosporium herbarum, while other compounds were inactive.

DOI

10.21608/bfsa.2007.64196

Authors

First Name

A.

Last Name

Ali

MiddleName

A.

Affiliation

Department of Pharamcocnosy, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt

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First Name

H.

Last Name

Hassanean

MiddleName

A.

Affiliation

Department of Pharamcocnosy, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt

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First Name

Ehab

Last Name

Elkhayat

MiddleName

S.

Affiliation

Department of Pharamcocnosy, Faculty of Pharmacy, Al-Azhar University (Assiut branch , 71524 Assiut, Egypt)

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First Name

Ru

Last Name

Edrada

MiddleName

AnGelie

Affiliation

Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, 40225 Düsseldorf, Germany

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First Name

Rainer

Last Name

Ebel

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-

Affiliation

Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, 40225 Düsseldorf, Germany

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Orcid

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First Name

Peter

Last Name

Proksch

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-

Affiliation

Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, 40225 Düsseldorf, Germany

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Volume

30

Article Issue

2

Related Issue

9610

Issue Date

2007-12-01

Receive Date

2007-09-04

Publish Date

2007-12-01

Page Start

149

Page End

157

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 30_Issue 2_Pages 149-157.pdf

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Link

https://bpsa.journals.ekb.eg/article_64196.html

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https://bpsa.journals.ekb.eg/service?article_code=64196

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IMIDAZOLE ALKALOIDS FROM THE INDOPACIFIC SPONGE PERICHARAX HETERORAPHIS

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Article

Created At

22 Jan 2023