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63356

CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE ROOTS OF SONCHUS OLERACEUS L. GROWING IN EGYPT

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Last updated: 25 Dec 2024

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Abstract

Phytochemical study of the roots of Sonchus oleraceus L.
(Astraceae) growing in Egypt, afforded loliolide 1 for the first time
from the genus Sonchus in addition to 15-O-β-glucopyranosyl-
11β,13-dihydrourospermal A 2, ursolic acid 3, lupeol 4, and β-
sitosterol-3-O-β-glucopyranoside 5 for the first time from the
species. The biological evaluation of the isolated compounds
showed cytotoxic activity of 1 and 2 against L5187Y cell line, while
compound 2 showed activity against PC33 cell line. In addition to
antibacterial activity of compounds 1 and 2 against S. aureus, B.
subtilis, E. Coli, and N. gonorrhoea. The structures of the isolated
compounds were elucidated using 1D (1H and 13C), 2D (H-H
COSY, HMQC and HMBC) NMR and MS spectroscopic data.

DOI

10.21608/bfsa.2009.63356

Authors

First Name

Ehab

Last Name

Elkhayat

MiddleName

Saad

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut 71524, Egypt

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Volume

32

Article Issue

1

Related Issue

9568

Issue Date

2009-06-01

Receive Date

2009-03-12

Publish Date

2009-06-30

Page Start

189

Page End

197

Print ISSN

1110-0052

Online ISSN

3009-7703

Link

https://bpsa.journals.ekb.eg/article_63356.html

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https://bpsa.journals.ekb.eg/service?article_code=63356

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE ROOTS OF SONCHUS OLERACEUS L. GROWING IN EGYPT

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Article

Created At

22 Jan 2023