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63272

SYNTHESIS OF SUBSTITUTED DIHYDROPYRIMIDINES AS HYPOTENSIVE AGENTS

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Last updated: 25 Dec 2024

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Abstract

A series of Dihydropyrimidines (DHPMs) with variable substituents at four positions in pyrimidine nucleus (I-IV), were prepared and tested for their calcium channel blocker and hypotensive effect using amlodipine as a reference compound. Molecular alignment revealed a direct correlation between fitting and in-vitro rat ileum relaxation. A pharmacophore was developed for compounds with hypotensive and/or calcium channel blocking activity. Series IV showed hypotensive and calcium antagonist effect, while series I and II showed calcium antagonist activity without hypotensive action. Series III were devoid of either effect.

DOI

10.21608/bfsa.2011.63272

Authors

First Name

Salah

Last Name

Abdel-Aziz

MiddleName

A.

Affiliation

Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Al-Azhar University

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Orcid

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First Name

Nawal

Last Name

El-Koussi

MiddleName

A.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University

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-

Orcid

-

First Name

Hoda

Last Name

Hassan

MiddleName

Y.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University

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City

-

Orcid

-

First Name

Adel

Last Name

Youssef

MiddleName

F.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University

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City

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Orcid

-

First Name

Magda

Last Name

Yousri

MiddleName

M.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University

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Volume

34

Article Issue

2

Related Issue

9557

Issue Date

2011-12-01

Receive Date

2011-09-12

Publish Date

2011-12-31

Page Start

159

Page End

179

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 34_Issue 2_Pages 159-179.pdf

PDF . 787.8kB

Link

https://bpsa.journals.ekb.eg/article_63272.html

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https://bpsa.journals.ekb.eg/service?article_code=63272

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS OF SUBSTITUTED DIHYDROPYRIMIDINES AS HYPOTENSIVE AGENTS

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Article

Created At

22 Jan 2023