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65789

PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES

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Last updated: 25 Dec 2024

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Abstract

Five compounds (1-5) were firstly reported from the genus Centaurium family Gentianaceae. They were identified as Lisianthoside 1, Secoxyloganin 2, Secologanin dimethyl acetal 3, 1,8-Dihydroxy-3,5,6,7-tetramethoxyxanthone (Demethyleustomin) 4 and 1-Hydroxy3,5,6,7,8-pentamethoxyxanthone (Eustomin) 5. Structure elucidation was carried out with support of chemical and spectral analysis including 1D and 2D NMR experiments. All the isolated compounds showed promising antioxidant activity, liver microsomal enzymes reducing activity and CYP3A4 mRNA inhibition activity in the HepG2 cell line.
 
 

DOI

10.21608/bfsa.2014.65789

Authors

First Name

Ahmed

Last Name

Allam

MiddleName

E.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

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First Name

Mohamed

Last Name

El-Shanawany

MiddleName

A.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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Orcid

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First Name

Enaam

Last Name

Backheet

MiddleName

Y.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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City

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Orcid

-

First Name

Alaa

Last Name

Nafady

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

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Volume

37

Article Issue

2

Related Issue

9487

Issue Date

2014-12-01

Receive Date

2014-06-24

Publish Date

2014-12-31

Page Start

65

Page End

76

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 37_Issue 2_Pages 65-76.pdf

PDF . 817.4kB

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https://bpsa.journals.ekb.eg/article_65789.html

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https://bpsa.journals.ekb.eg/service?article_code=65789

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Original Article

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1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PHYTOCHEMICAL INVESTIGATION OF THE AERIAL PARTS OF CENTAURIUM SPICATUM WITH HEPATOPROTECTIVE AND mRNA ENZYMATIC INHIBITION ACTIVITIES

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Article

Created At

22 Jan 2023