Beta
ManageSearchChatDiscover
62602

INTERACTIONS OF CELECOXIB WITH DIFFERENT ANTIDIABETIC DRUGS IN DIABETIC RATS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The selective cyclooxygenase-2 inhibitor, celecoxib, can be prescribed to type 2 diabetic patients receiving oral hypoglycemic agents. This study was conducted to assess whether celecoxib affect the hypoglycemic activity of oral hypoglycemic agents in streptozotocin-induced diabetic rats by measuring blood glucose level followed by determination of glucose uptake of isolated rat epididymal fat pads. Also, the effect of anti-diabetic agents on the anti-inflammatory activity of celecoxib was also assessed using carrageenan-induced hind paw edema model in diabetic rats.This study revealed that the effect of celecoxib on the hypoglycemic activity of glibenclamide was additive and can be explained by stimulation of tissue glucose uptake by celecoxib. On the other hand, the effect of celecoxib on the hypoglycemic activity of glimepiride was not simple additive but synergistic. This synergistic effect can be explained not only by stimulation of tissue glucose uptake by celecoxib but also via a pharmacokinetic interaction by increasing the serum glimepiride concentration.

DOI

10.21608/bfsa.2016.62602

Authors

First Name

Manar

Last Name

Nader

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, El-Madinah El-Munawarah, Saudi Arabia and Faculty of Pharmacy, Mansoura University, Mansoura, Egypt , Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Shehta

Last Name

Said

MiddleName

A.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

Manar

Last Name

Helal

MiddleName

G.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

Volume

39

Article Issue

1

Related Issue

9479

Issue Date

2016-12-01

Receive Date

2016-05-26

Publish Date

2016-12-31

Page Start

73

Page End

86

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 39_Issue 1_Pages 73-86.pdf

PDF . 306.0kB

Link

https://bpsa.journals.ekb.eg/article_62602.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=62602

Order

5

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INTERACTIONS OF CELECOXIB WITH DIFFERENT ANTIDIABETIC DRUGS IN DIABETIC RATS

Details

Type

Article

Created At

22 Jan 2023