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62589

SYNTHESIS OF NOVEL PYRAZOLE DERIVATIVES BEARING 1,2,4-TRIAZOLE MOIETY AS POTENTIAL ANTICANCER AGENTS

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Last updated: 04 Jan 2025

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Abstract

A series of novel3-(1H-pyrazol-3-yl)-4H-1,2,4-triazole derivatives were synthesized and the structure of the prepared compounds was fully characterized by 1H NMR, 13C NMR, and HRESI-MS. Six of the prepared compounds were screened for in-vitro cytotoxicity against different cancer cell lines at National Cancer Institute (NCI), USA. Compound 7e exhibited a broad-spectrum of anticancer activity against different cancer cell lines without pronounced selectivity. Moreover, the anticancer activity of the prepared compounds was also evaluated against different human cancer cell lines including breast MCF-7, lung A549 as well as the human normal melanocyte (HFB4) using doxorubicin as a reference drug. Compounds 7l and 7o exhibited remarkable anticancer activity similar to or more potent than doxorubicin against breast MCF-7 and Lung A549 cell lines.

DOI

10.21608/bfsa.2016.62589

Authors

First Name

Mostafa

Last Name

Abdelrahman

MiddleName

H.

Affiliation

Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

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First Name

Mamdouh

Last Name

Ali

MiddleName

M.

Affiliation

Department of Biochemistry, Division of Genetic Engineering and Biotechnology, National Research Centre, Dokki 12622, Giza, Egypt

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Volume

39

Article Issue

1

Related Issue

9479

Issue Date

2016-12-01

Receive Date

2016-02-16

Publish Date

2016-12-31

Page Start

53

Page End

71

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 39_Issue 1_Pages 53-71.pdf

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https://bpsa.journals.ekb.eg/article_62589.html

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https://bpsa.journals.ekb.eg/service?article_code=62589

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SYNTHESIS OF NOVEL PYRAZOLE DERIVATIVES BEARING 1,2,4-TRIAZOLE MOIETY AS POTENTIAL ANTICANCER AGENTS

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Article

Created At

22 Jan 2023