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62583

FORMULATION AND EVALUATION OF ORAL SUSTAINED RELEASE ETHYL CELLULOSE MICROPARTICLES INCORPORATED WITH FLURBIPROFEN

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Last updated: 25 Dec 2024

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Abstract

A great effort has been devoted to develop a method for delivering an efficient potent analgesic drug flurbiprofen (FLB) into more absorbed and small polymeric microparticles ethyl cellulose (EC), moreover to avoid the absorption at the acidic pH of the stomach. EC microparticles loaded with FLB were prepared by emulsion-solvent evaporation. A complete study for the encapsulation efficiency percent (EE%), the size and weight of the microparticles incorporated with FLB were studied and optimized. The release profiles of FLB from EC microparticles were measured in Sorensen phosphate buffer (0.1 M, pH 7.4). The results showed that EE% for all forms of microparticles was decreased as drug : polymer ratios decreased. The microparticles had a mean diameter of 30-80 µm as showed by scanning electron microscopy, confirming that the structure was in micro-size, moreover the release rate of FLB from microparticles was strikingly lower than that from drug itself. The results allow for the conclusion that the formulated microparticles serve as promising platform to improve the solubility, absorption and sustained release of FLB.

DOI

10.21608/bfsa.2016.62583

Authors

First Name

Ahmed

Last Name

Abdellatif

MiddleName

A. H.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt

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First Name

Mohamed

Last Name

El Hamd

MiddleName

-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt

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Orcid

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First Name

Ramadan

Last Name

Ali

MiddleName

-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt

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City

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Orcid

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First Name

Khaled

Last Name

Saleh

MiddleName

I.

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt

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Orcid

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Volume

39

Article Issue

1

Related Issue

9479

Issue Date

2016-12-01

Receive Date

2015-11-26

Publish Date

2016-12-01

Page Start

27

Page End

41

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 39_Issue 1_Pages 27-41.pdf

PDF . 550.6kB

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https://bpsa.journals.ekb.eg/article_62583.html

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https://bpsa.journals.ekb.eg/service?article_code=62583

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION AND EVALUATION OF ORAL SUSTAINED RELEASE ETHYL CELLULOSE MICROPARTICLES INCORPORATED WITH FLURBIPROFEN

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Article

Created At

22 Jan 2023