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62467

NARINGIN PREVENT CISPLATIN-INDUCED NEPHROTOXICITY BY ABROGATION OF OXIDATIVE STRESS AND INFLAMMATION IN RATS

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Last updated: 25 Dec 2024

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Abstract

Nephrotoxicity remains one of the most dangerous effect relevant to cisplatin use in chemotherapy. Rat injection with cisplatin in a single dose of 7 mg/kg intraperitoneally resulted in a significant increase in serum level of urea and creatinine. Also, cisplatin caused marked increase in renal content of malondialdehyde (MDA), while depletion in reduced glutathione (GSH). In addition, cisplatin administration notably increased kidney/body weight ratio, renal contents of nitric oxide (NO), tumor necrosis factor alpha(TNF-α) and cyclooxygenase-2 (COX-2) protein level as well as renal myeloperoxidase (MPO) activity. Histopathological examination confirmed the biochemical and molecular results which revealed several pathological alteration in the renal tissues following cisplatin. Oral pretreatment of rats with naringin (NAR) (80 mg/kg) for 14 days before and 7 days after cisplatin injection significantly reduced the pathological level of serum urea and creatinine and restored oxidative stress parameters. In the same manner, the inflammatory markers as well as kidney/body weight ratio show great improvement following the treatment. The histopathological examination confirms fit with the biochemical and molecular results. In conclusion, NAR showed a great protective effect against cisplatin-induced nephrotoxicity in rats via its antioxidant, anti-inflammatory roles.

DOI

10.21608/bfsa.2018.62467

Authors

First Name

Abd-Elmoniem

Last Name

Taha

MiddleName

A.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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First Name

M.

Last Name

Khalifa

MiddleName

M.A.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Egypt

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Orcid

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First Name

Mohamed

Last Name

Abd El-Salam

MiddleName

I.

Affiliation

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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Volume

41

Article Issue

1

Related Issue

9467

Issue Date

2018-12-01

Receive Date

2018-04-26

Publish Date

2018-12-31

Page Start

45

Page End

54

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 41_Issue 1_Pages 45-54.pdf

PDF . 2.6MB

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https://bpsa.journals.ekb.eg/article_62467.html

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https://bpsa.journals.ekb.eg/service?article_code=62467

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

NARINGIN PREVENT CISPLATIN-INDUCED NEPHROTOXICITY BY ABROGATION OF OXIDATIVE STRESS AND INFLAMMATION IN RATS

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Article

Created At

22 Jan 2023