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62464

FORMULATION OF 5-FLUOROURACIL MICROSPONGES AS COLON TARGETED DELIVERY SYSTEM USING 32 FACTORIAL DESIGN

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Last updated: 25 Dec 2024

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Abstract

5-Fluorouracil is widely used for treatment of colorectal cancer and is provided as intravenous bolus or infusion because it has erratic oral bioavailability. Diarrhea and myelosuppression are potential and the major side effects of the intravenous administration route. This work was aimed to develop colon-targeted delivery of 5-Fluorouracil microsponges so that, the oral bioavailability enhanced and the side effects could be potentially reduced. Quassi-emulsion solvent diffusion method was used to prepare 5-Fluorouracil microsponges using polyethylene glycol as an emulsifier. Different formulae were prepared with different composition and processing factors. The entrapment efficiency 5-Fluorouracil in these formulae ranged from 17.81 to 78.61%, the particle size of the prepared microsponges ranged from 87 to 229 µm and the % cumulative drug released after 24 hours ranged from 47.7 to 98.58%. The prepared microsponges were subjected to compatibility studies as Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Thus 5-fluorouracil microsponges considered as a promising system for the colon-specific delivery that has potential for future use as an anticancer therapy for colorectal cancer.

DOI

10.21608/bfsa.2018.62464

Authors

First Name

Ahmed

Last Name

Ali

MiddleName

U.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt

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Orcid

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First Name

Mahmoud

Last Name

El-Badry

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt

Email

elbadry@aun.edu.eg

City

-

Orcid

-

First Name

Tahani

Last Name

Elfaham

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Asyut University, Asyut 71526, Egypt

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-

City

-

Orcid

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Volume

41

Article Issue

1

Related Issue

9467

Issue Date

2018-12-01

Receive Date

2017-12-11

Publish Date

2018-12-31

Page Start

31

Page End

44

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 41_Issue 1_Pages 31-44.pdf

PDF . 2.2MB

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https://bpsa.journals.ekb.eg/article_62464.html

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https://bpsa.journals.ekb.eg/service?article_code=62464

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION OF 5-FLUOROURACIL MICROSPONGES AS COLON TARGETED DELIVERY SYSTEM USING 32 FACTORIAL DESIGN

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Article

Created At

22 Jan 2023