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62263

ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION

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Last updated: 25 Dec 2024

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Abstract

Liposomes are used for systemic delivery of chemotherapeutic drugs to reduce their nonspecific side effects. Liposomes can encapsulate hydrophilic and lipophilic drugs in the water compartment and the lipid membrane, respectively. However, typical drug loading capacity of liposomes by passive loading method is less than 1%. The low drug loading efficiency is problematic because it necessitates the use of a large amount of carrier materials that may cause undesirable biological effects. To increase drug loading in liposomes, weusedsupersaturated drug solutionswith gemcitabine (GEM) and doxorubicin (Dox) as examples. The prepared liposomes showed higher drug loading compared with passive loading, maintainedstabilityand provided sustained drug release for 48 hrs.

DOI

10.21608/bfsa.2019.62263

Authors

First Name

Hassan

Last Name

Tamam

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-

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA

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Orcid

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First Name

Jelan

Last Name

Abdel-Aleem

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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-

Orcid

-

First Name

Sayed

Last Name

Abdelrahman

MiddleName

I.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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-

Orcid

-

First Name

Aly

Last Name

Abdelrahman

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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City

-

Orcid

-

First Name

Yoon

Last Name

Yeo

MiddleName

-

Affiliation

Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA

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Volume

42

Article Issue

1

Related Issue

9386

Issue Date

2019-11-01

Receive Date

2019-04-24

Publish Date

2019-12-31

Page Start

31

Page End

38

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 42_Issue 1_Pages 31-38.pdf

PDF . 727.0kB

Link

https://bpsa.journals.ekb.eg/article_62263.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=62263

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4

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION

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Article

Created At

22 Jan 2023