Aims: The objective of this study is to evaluate healing effect of topical Apigenin cream 2% in the skin of rabbits .Materials and Methods: 24 healthy Newzealand adult male rabbits approximately same age were involved in this study, , all animals anesthetized using mixture of 40 mg/kg ketamine injection and xylazine 4 mg/kg intramuscularly , The skin of the dorsum area of each rabbit was shaved, then three incisions (1cm in length) were made on the skin with scalpel blade no.15. Wounds were left without suturing to heal by secondary intention healing, and each animal had three wounds ( wounds divided into three groups according to the type of treatment): one treated with Apigenin cream twice a day, the other with cold cream twice a day, and the third wound was left untreated. The application of cream was repeated daily, the wound size and the ratio of wound contraction assessed at first, fourth and seventh days of study. Results : group treated with Apigenin showed significantly better wound healing capacity in the skin of rabbits, wound size and wound contraction ratio was superior in Apigenin group in comparison to control positive and negative groups. Conclusion : Apigenin cream enhance wound healing potential of skin in rabbits .