This review was intended to elucidate the role of antioxidants in poultry feed formula on bird's ecophysiology. Naturally, many compounds have antioxidant features, including fat and water-soluble compounds, which can either be synthesized by the body or supplemented with a diet. The additive of antioxidants on poultry fodder is usually utilized in order to elevate the steadiness of feed. Nevertheless, some antioxidants are believed to have biological consequences in vivo. Oxidative stress clues to biological destruction, which in turn can disturb growth and production in farmstead animals. These Stressful factors are created reactive oxygen species. Therefore, the natural and synthetic antioxidants that add to animal feed are important to diminish the free radicals that are thought to unfavorably on growth, immune status, elevated lipid rancidity, and poor quality of meat. Supplementation of balanced feed with many ingredients including natural and synthetic antioxidants will improve the bird's performance and other physiological aspects by reducing the significant effects of free radicals. In conclusion, feed additive including antioxidants integrated with feed formula is beneficial and valuable to exclude and prevent the destructive effects of reactive oxygen species on physiological aspects of vital organs, maintenance of homeostasis, Repair and removal of harmed particles, activation of apoptosis and finally limit of mutagenesis.