Beta
ManageSearchChatDiscover
140080

Improvement Of Inactivated Equine Herpes Virus-1 Vaccine Using Carbomer

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Immunology and Vaccinology

Abstract

An inactivated Equine herpes virus-1 vaccine was successfully improved using carbomer as adjuvant inducing high and long immunity in vaccinated mares in comparison with the convention one adjuvanted with Al-hydra gel and saponin. Such purpose was established by using 0.5% carbomer as adjuvant to the inactivated EHV-1. The applied quality control tests carried out on such vaccine revealed that it is free from foreign contaminants, safe in pregnant mares and mice and potent induced high levels of specific EHV-1 antibodies in vaccinated Guinea pigs and mares as measure by ELISA and SNT. This immunity was sufficient to protect vaccinated horses up to 28 weeks (7months) post-vaccination.

DOI

10.21608/javs.2021.140080

Keywords

Carbomer, ELISA, SNT, Inactivated EHV-1, Equine Virus

Authors

First Name

Safaa

Last Name

A. Warda

MiddleName

-

Affiliation

Department of Equine Vaccines Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt

Email

-

City

-

Orcid

-

First Name

Naglaa

Last Name

I. Ali

MiddleName

-

Affiliation

Department of Pet Animal Vaccines Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.

Email

-

City

-

Orcid

-

First Name

Fatma

Last Name

F. Warda

MiddleName

-

Affiliation

Department of Equine Vaccines Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.

Email

-

City

-

Orcid

-

First Name

Ekbal

Last Name

Farouk

MiddleName

M.

Affiliation

Department of Foot and Mouth Disease Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.

Email

dr.e_farouk@yahoo.com

City

-

Orcid

-

First Name

Lubna

Last Name

F. Farahat

MiddleName

-

Affiliation

Department of Sera and Antigens Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agricultural Research Center (ARC), Egypt.

Email

-

City

-

Orcid

-

Volume

6

Article Issue

1

Related Issue

20722

Issue Date

2021-01-01

Receive Date

2020-11-16

Publish Date

2021-01-16

Page Start

21

Page End

27

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 6_Issue 1_Pages 21-27.pdf

PDF . 561.9kB

Link

https://javs.journals.ekb.eg/article_140080.html

Detail API

https://javs.journals.ekb.eg/service?article_code=140080

Order

4

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Improvement Of Inactivated Equine Herpes Virus-1 Vaccine Using Carbomer

Details

Type

Article

Created At

22 Jan 2023