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103395

Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Immunology and Vaccinology

Abstract

In a trail to improve rabies vaccine's immunogenicity, water-soluble acrylic acid (carbopol) was used as an adjuvant in the prepared vaccine. The potency test of the National Institute of Health revealed that the prepared vaccine is potent and efficient. Studying the dynamics of serum antibody in vaccinated dogs using serum neutralizing antibodies test and ELISA showed that antibody titer (0.9 and 1.2352 respectively) reached a level considered protective within two weeks and increased till lasted consist ant (2.4 and 2.694)  during the experiment for about twenty-four weeks. In conclusion, the present study results indicated that the vaccine formulated according to this study procedure could provoke long-lasting protective immune response after a single dose administration without any adverse reaction.

DOI

10.21608/javs.2020.103395

Keywords

Carbopol, ELISA, inactivated vaccine, rabies

Authors

First Name

Naglaa

Last Name

Aly

MiddleName

I.

Affiliation

Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI) Abbasia Cairo Egypt

Email

naglaaaly20093@yahoo.com

City

Cairo

Orcid

-

First Name

Omaima

Last Name

A. E. El-Shamandy

MiddleName

-

Affiliation

Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center, Abassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Shendy

Last Name

M.B.

MiddleName

-

Affiliation

Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center, Abassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Fatma

Last Name

F. Warda

MiddleName

-

Affiliation

Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center, Abassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Ekbal

Last Name

M. Farouk

MiddleName

-

Affiliation

Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center, Abassia, Cairo, Egypt.

Email

-

City

-

Orcid

-

Volume

5

Article Issue

3

Related Issue

12904

Issue Date

2020-07-01

Receive Date

2020-06-23

Publish Date

2020-07-01

Page Start

103

Page End

107

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 5_Issue 3_Pages 103-107.pdf

PDF . 559.7kB

Link

https://javs.journals.ekb.eg/article_103395.html

Detail API

https://javs.journals.ekb.eg/service?article_code=103395

Order

12

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Efficacy Of Using Carbopol As An Adjuvant For Tissue Culture Inactivated Rabies Vaccine

Details

Type

Article

Created At

22 Jan 2023