The ideal adjuvant is one that able to aid in early stimulation of the humeral immune response, and to promote the production of high antibody titers that would persist for long duration as well as stimulate the cellular immune response. This immunological study was conducted to reveal the aluminum hydroxide gel effect with the use of oil adjuvants on the immune response of  polyvalent foot  and  mouth  disease (FMD) vaccine  in  sheep. Twenty five sheep, were divided to five group (five animals/group) where the 1^st group was vaccinated with polyvalent FMD ISA 206 oil vaccine, 2^nd group was vaccinated with polyvalent FMD ISA 206 + aluminum hydroxide gel vaccine, 3^rd group was vaccinated with polyvalent ISA 201 oil vaccine, 4^th group was vaccinated with polyvalent ISA 201 + aluminum hydroxide gel vaccine, 5^th group was kept as a negative control (non-vaccinated). Blood and Serum samples were collected from vaccinated animals for monitoring the cellular and humoral immune responses. The results showed that sheep groups immunized with the vaccine prepared with ISA 201with aluminum hydroxide gel is considered the best cellular and humeral immunity post vaccinal response then ISA 201 followed by ISA 206 with aluminum hydroxide gel and the last one is the vaccine prepared with ISA 206 alone.It can be concluded that ISA oils with aluminum hydroxide gel induce the best cellular and humeral immunity.