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85584

Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits

Article

Last updated: 25 Dec 2024

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Tags

Poultry diseases

Abstract

This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal saline. Group II, III, and IV were daily administrated with PTU in oral dosing of 50, 75, and 150 mg/kg, BWT, respectively, for three successive weeks. Serum T3 and T4 levels were measured in all groups. Increased serum creatinine and blood urea nitrogen levels (P<0.05) were also associated. Moreover, liver enzymes levels, aspartate aminotransferase, alanine aminotransferase, and total serum cholesterol levels showed a significant increase in a dose and time decedent manner. Thyroid glands of PTU-treated rabbits showed variable sized-follicles lined by multiple layers of follicular cells, which displayed signs of hyperactivity as the average follicular cell height. The diameter of its width was significantly increased compared with that in the control group. Besides, follicles were filled with a variable quantity of low-dense vacuolated colloids. Kidneys of such animals showed tubulointerstitial nephritis, glomerular atrophy, and multiple focal areas of mononuclear cell reaction. While the observed hepatic lesions were in the form of severe congestion in central vein and hepatic artery, hepatocellular necrosis, and granulocytic lymphoid cellular responses around portal areas associated with peri-portal fibrosis. Such lesions were dependent on doses of PTU. This study referred to that continuous treatment with an antithyroid drug PTU induced a hypothyroid state that was associated with impaired renal and hepatic functions in rabbits. 

DOI

10.21608/javs.2020.85584

Keywords

Propylthiouracil, PUT, Rabbits, Renal dysfunction

Authors

First Name

Omnia

Last Name

S. Farrag

MiddleName

-

Affiliation

Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut; 71526, Egypt.

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

Salman

MiddleName

-

Affiliation

Department of Animal Medicine, Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Sohag, University, Sohag, 82524, Egypt

Email

-

City

-

Orcid

-

First Name

Fatma

Last Name

Ali

MiddleName

Abo Zakaib

Affiliation

Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Sohag, University, Egypt.

Email

-

City

-

Orcid

-

First Name

Arafat

Last Name

S. Sayed

MiddleName

-

Affiliation

Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut; 71526, Egypt.

Email

-

City

-

Orcid

-

First Name

Motamed

Last Name

Mahmoud

MiddleName

E.

Affiliation

Professor of Animal Behaviour and Management, Faculty of Veterinary Medicine. Sohag University, Egypt

Email

motamed71111@gmail.com

City

Sohag

Orcid

-

First Name

Abd-El Raheem

Last Name

A. Abd-El Raheem

MiddleName

-

Affiliation

Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut; 71526, Egypt.

Email

-

City

-

Orcid

-

Volume

5

Article Issue

2

Related Issue

12838

Issue Date

2020-04-01

Receive Date

2020-02-03

Publish Date

2020-04-25

Page Start

49

Page End

60

Print ISSN

1687-4072

Online ISSN

2090-3308

Article File

JAVS_Volume 5_Issue 2_Pages 49-60.pdf

PDF . 1.7MB

Link

https://javs.journals.ekb.eg/article_85584.html

Detail API

https://javs.journals.ekb.eg/service?article_code=85584

Order

7

Type

Original Article

Type Code

1,095

Publication Type

Journal

Publication Title

Journal of Applied Veterinary Sciences

Publication Link

https://javs.journals.ekb.eg/

MainTitle

Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits

Details

Type

Article

Created At

22 Jan 2023