In the present study, a therapeutic trial was conducted to assess comparative efficacy of Terlipressin acetate in dogs suffering from hemorrhagic gastroenteritis (HGE). 70 dogs manifesting HGE, presented at teaching veterinary clinic, were selected randomly for the trial. All of them were observed to suffer from moderate dehydration on clinical examination. Terlipressin acetate, dextrose saline infusion 5% were used in combination with antibiotics and symptomatic treatment in the first group and in the second group, the dextrose saline infusion 5%, antibiotics and symptomatic treatment were used, both groups consisting of 35 cases each. The outcome of both treatment groups was evaluated on hematobiochemical parameters, before and after administration of the therapies and compared statistically within and between the two groups. Hematobiochemical parameters of clinically healthy animals were considered as control for comparison. On hematobiochemical examination, no significant alterations were observed in first group and second group. Clinical recovery was faster in the first group than the second group of animals. Laboratory data, efficacies of the Terlipressin acetate were of low importance for recovery in small animals suffering from hemorrhagic gastroenteritis (HGE).