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69025

A Review of the Methods for Detecting and Characterizing DNA Methylation as a Cancer Biomark

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Last updated: 25 Dec 2024

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Abstract

DNA methylation is a covalent alteration in the DNA genome that modifies the expression of gene. DNA methylation occurs by adding methyl group to DNA molecule at fifth carbon of Cytosine ring. This process alters DNA activities but doesn't change the sequence. This modification may cause tumorigenesis and cancer progression. Therefore, there is an urgently need to detect the methylated sites in DNA sequences and their regulation mechanisms which effect the epigenetics transformation. Predominantly, these epigenetic changes are in small regions in DNA called CpG islands, which exist with various frequencies in DNA sequences but mostly detected in promoter regions. Recently, a lot of efforts have been dedicated to computationally detect CpG islands, build large-scaled databases with visualization tools and develop analysis methods for DNA methylation data. Here, we provide a review on CpG islands detectors and classifier algorithms. We focus on genome-wide methylation databases of human cancers. We present an overview of methodologies available for DNA deferential methylation analysis. We aimed to summarize the recent efforts in DNA methylation changes and their significance in human cancers to open the door for more development in mechanisms and treatment perspectives.

DOI

10.21608/mjeer.2019.69025

Keywords

Epigenetics, DNA Methylation, hypo-methylation, hyper-methylation, Mutation, carcinogenesis

Authors

First Name

Sheren

Last Name

A. El-Booz

MiddleName

-

Affiliation

Computer Science and Engineering. Faculty of Electronic Engineering. Menofia University, Menouf, Egypt

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Orcid

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First Name

Marwa

Last Name

A. Radad

MiddleName

-

Affiliation

Computer Science and Engineering. Faculty of Electronic Engineering. Menofia University, Menouf, Egypt

Email

-

City

-

Orcid

-

First Name

Nawal A

Last Name

El-Fishawy

MiddleName

-

Affiliation

Computer Science and Engineering. Faculty of Electronic Engineering. Menofia University, Menouf, Egypt

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Attiya

MiddleName

-

Affiliation

Computer Science and Engineering. Faculty of Electronic Engineering. Menofia University, Menouf, Egypt

Email

gamal.attiya@yahoo.com

City

-

Orcid

0000-0002-4771-9165

Volume

28

Article Issue

ICEEM2019-Special Issue

Related Issue

9704

Issue Date

2019-12-01

Receive Date

2020-01-23

Publish Date

2019-12-08

Page Start

311

Page End

318

Print ISSN

1687-1189

Online ISSN

2682-3535

Link

https://mjeer.journals.ekb.eg/article_69025.html

Detail API

https://mjeer.journals.ekb.eg/service?article_code=69025

Order

19

Type

Original Article

Type Code

1,088

Publication Type

Journal

Publication Title

Menoufia Journal of Electronic Engineering Research

Publication Link

https://mjeer.journals.ekb.eg/

MainTitle

A Review of the Methods for Detecting and Characterizing DNA Methylation as a Cancer Biomark

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Type

Article

Created At

22 Jan 2023