In recent years, industrial pollution to water, soil and plants is getting to be toxic and very harmful to the animal and human life. In this study, Seventy adult cattle over 4 years old collected from a private farms adjacent to industrial areas of copper smelters in Sharkia province. These Cows also kept grassing for several years on a Fields and pastures which was previously sprayed and treated with antifungals and other insecticides containing 8% copper sulphate. Thirty five of the livestock (50%) showed clinical signs of chronic copper poisoning in the farm of loss appetite, emaciation, diarrhoea, haematuria and jaundice. Five of the diseased cows were emergency slaughtered. Water, soil, Feedstuffs, blood and tissues samples were collected and revealed a high concentration of copper than the recommended permissible limits of WHO (1995). The copper poisoning influenced the serum biochemical constituents showning a significant increase in the levels of serum alanine aminotransferase (S.ALT), aspartate aminotranferase (S.AST), serum alkaline pohsphatase enzyme (S.AP) zinc, iron urea and creatinine, while there were a highly significant decrease of serum total protein, albumin, sodium and potassium. Haematological studies showed normocytic normochromic anaemia represented by significant decrease of redblood cells count (RBCs), haemoglobin content (Hb) and Packed cell volume (PCV) accompanied by leucocytosis. The public health hazard toxic effects of copper residues for animals and human was discussed and suggestive recommendations to protect consumers were recorded.