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115882

AN IMMUNOHISTOCHEMICAL STUDY ON ESTROGEN RECEPTOR-ALPHA (ER-Α) EXPRESSION IN THE RABBIT UTERUS DURING EARLY PREGNANCY AND PSEUDOPREGNANCY

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Veterinary Anatomy, Histology and Physiology “Veterinary Academic Studies".

Abstract

Estrogen is essential factor for establishment of normal pregnancy in mammals. Estrogenic action in uterus was found to be mediated by intracellular, primarily nuclear receptor called estrogen receptor-alpha (ER-α). In the current study; immunohistochemistry was used to localize ER-α  in the uterus of pregnant and psudopregnant rabbits. ER-α was strongly expressed in non pregnant uteri in nearly all cellular compartments as luminal and glandular epithelium, stromal cells and myometrial smooth muscle cells. Marked down regulation of the ER-α in luminal but not in glandular epithelium was observed during early periods of pregnancy and pseudopregnancy. Weaker glandular staining was only observed during postimplantation periods. Stromal cells were always immunopositive even after implantation till day twelve of pregnancy. Myometrium was expressing the receptor till after implantation. ER-α was always nuclear in immunopositive cells. Our results revealed that,  ER-α was involved in the process of progestational proliferation in the rabbit uterus; in addition, the receptor expression is tissue specific and maternally controlled.

DOI

10.21608/kvmj.2007.115882

Keywords

estrogen receptor-alpha (ER-α), Immunohistochemistry, pregnant and psudopregnant rabbits

Authors

First Name

Atif

Last Name

Hasan

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University

Email

atif178@hotmail.com

City

-

Orcid

-

Volume

5

Article Issue

2

Related Issue

16823

Issue Date

2007-10-01

Receive Date

2007-07-01

Publish Date

2007-10-01

Page Start

56

Page End

73

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 5_Issue 2_Pages 56-73.pdf

PDF . 1.2MB

Link

https://kvmj.journals.ekb.eg/article_115882.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=115882

Order

3

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

AN IMMUNOHISTOCHEMICAL STUDY ON ESTROGEN RECEPTOR-ALPHA (ER-Α) EXPRESSION IN THE RABBIT UTERUS DURING EARLY PREGNANCY AND PSEUDOPREGNANCY

Details

Type

Article

Created At

22 Jan 2023