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111529

PHARMACOLOGICAL STUDY ON THE EFFECT OF DICLAZURIL AND SEMDURAMICIN ON THE IMMUNE RESPONSE IN BRIOLERS

Article

Last updated: 25 Dec 2024

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Subjects

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Tags

Veterinary Pharmacology, Toxicology and Forensic Medicine.

Abstract

The aim of the present workwas to study the effect of two anticoccidial drugs namely diclazuril and semduramicin on the immune response of briolers. Birds were divided into three equal groups, each of 50 chicks. The 1st .group received semduramicin (25 ppm). The 2nd group received diclazuril (1ppm) and 3rd group received only basal ration (control). All groups were vaccinated against Newcastle virus at 18 days and  were challenged with a  virulent strain of ND at the 21th day of age. Blood samples were collected from birds of each group at 25 days of the experiment. Five chickens of each group were slaughtered at the same age then the lymphoid organs (thymus, bursa and spleen) were carefully separated &weighed and each organ relative weight was determined.Number of dead birds were recorded daily till the end of the experiment (at 45 day). It was observed that administration of diclazuril and semduramicin in recommended doses has no significant changes on blood cell count. Moreover, the obtained results indicated that both drugs had no significant effects on createnine and uric acid serum levels and on the activities of  AST and ALT,. On the other hand, semduramicin induced a significant  decrease in the phagocytic activity, serum globulin  and HI titer. Additionally, semduramicin decreased the relative weights of bursa.

DOI

10.21608/kvmj.2013.111529

Keywords

diclazuril and semduramicin, immune response of briolers

Authors

First Name

M. F.

Last Name

El dakroury

MiddleName

-

Affiliation

Animal Health Research Institute, provisional lab Kafer El-Sheikh Pharmacology

Email

-

City

-

Orcid

-

First Name

W. F.

Last Name

Resik

MiddleName

-

Affiliation

Animal Health Research Institute, provisional lab Kafer El-Sheikh Pharmacology

Email

-

City

-

Orcid

-

Volume

11

Article Issue

2

Related Issue

16742

Issue Date

2013-10-01

Receive Date

2013-07-01

Publish Date

2013-10-01

Page Start

55

Page End

68

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 11_Issue 2_Pages 55-68.pdf

PDF . 699.2kB

Link

https://kvmj.journals.ekb.eg/article_111529.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=111529

Order

4

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

PHARMACOLOGICAL STUDY ON THE EFFECT OF DICLAZURIL AND SEMDURAMICIN ON THE IMMUNE RESPONSE IN BRIOLERS

Details

Type

Article

Created At

22 Jan 2023