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110202

PATHOLOGICAL EVALUATION OF DORSAL ROOT GANGLIA AND SPINAL CORD AND SCIATIC NERVE FOLLOWING A CHRONIC CONSTRICTION INJURY OF THE SCIATIC NERVE IN RATS

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Veterinary Anatomy, Histology and Physiology “Veterinary Academic Studies".

Abstract

Objective: To study pathological changes on spinal cord and dorsal root ganglia (DRG) and sciatic nerve itself after sciatic nerve injury in rats
Design: Randomized experimental study
Procedure:  Rats were randomly divided into two main groups. Control group (25 rats) without any treatment and treated group (n=50) with induced chronic constriction injury (CCI) of sciatic nerve. The rates of the treated groups were euthanized at intervals, 25 rats after two weeks and the other 25 rats at 4 weeks after injury. Histopathological examinations of sciatic nerve, spinal cord and DRG for each group were done.
Results: The sensory neurons of the DRG displayed chromatolysis at two weeks post-injury, while chromatolysis, satellitosis and microgliosis were evident at four weeks post-injury. Wallerian degeneration in the sciatic nerve, and inflammatory cells recruitment with glial cells proliferation in spinal cord, was consistent at four weeks of CCI.
Conclusion and clinical relevance:  We concluded that DRG showed deleterious pathological alterations in the sensory neurons following sciatic nerve injury in rats.

DOI

10.21608/kvmj.2019.110202

Keywords

Chronic constriction injury, dorsal root ganglia, Spinal cord, Rats

Authors

First Name

Al-Shimaa E

Last Name

Elsayed

MiddleName

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Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.

Email

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City

-

Orcid

-

First Name

Walaa F

Last Name

Awadin

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.

Email

-

City

-

Orcid

-

First Name

Marwa E

Last Name

Abass

MiddleName

-

Affiliation

Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 5516, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed F

Last Name

Hamed

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.

Email

-

City

-

Orcid

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Volume

17

Article Issue

1

Related Issue

16741

Issue Date

2019-04-01

Receive Date

2019-01-01

Publish Date

2019-04-01

Page Start

63

Page End

77

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 17_Issue 1_Pages 63-77.pdf

PDF . 663.7kB

Link

https://kvmj.journals.ekb.eg/article_110202.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=110202

Order

4

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

PATHOLOGICAL EVALUATION OF DORSAL ROOT GANGLIA AND SPINAL CORD AND SCIATIC NERVE FOLLOWING A CHRONIC CONSTRICTION INJURY OF THE SCIATIC NERVE IN RATS

Details

Type

Article

Created At

22 Jan 2023