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112450

PHARMACOLOGICAL STUDY ON THE EFFECT OF DICLAZURIL AND FLAVOMYCIN ON THE IMMUNE RESPONSE IN CHICKENS

Article

Last updated: 25 Dec 2024

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Subjects

-

Tags

Veterinary Pharmacology, Toxicology and Forensic Medicine.

Abstract

The present study was conducted to evaluate diclazuril at the recommended and its two folds doses (1 & 2 ppm), flavomycin at 75 gm/ton and their combinations on the immune response in chickens vaccinated with IBD vaccine. Diclazuril displayed a dose dependent immunity suppression. In the recommended dose, it did not harm the bird immunity. While, in double recommended dose, it significantly suppressed the chicken immune response to IBD virus vaccine. The depressed response was reflected as a decreased bursal weight, skin hypersensitivity, total leucocytic count, lymphocyte count, antibody titer, serum protein and  serum globulins. While, flavomycin at 75 gm/ton had no detectable effect on the bird immune response to IBD virus vaccine. The combinations between diclazuril (as an anticoccidial drug) and flavomycin (as a growth promotor) have no drug interaction in our experiment.

DOI

10.21608/kvmj.2005.112450

Keywords

diclazuril, Flavomycin, Immune Response, chickens

Authors

First Name

M.I

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Pharmacology Dep., Fac. of Vet. Med., Tanta University (Kafr El-Sheikh)

Email

-

City

-

Orcid

-

First Name

A.A.

Last Name

Zahra

MiddleName

-

Affiliation

Pharmacology Dep., Fac. of Vet. Med., Tanta University (Kafr El-Sheikh)

Email

-

City

-

Orcid

-

First Name

I.A.

Last Name

El-Seedi

MiddleName

-

Affiliation

Animal Health Research Institute, El-Dokki, Giza

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

Abdel-Hafez

MiddleName

-

Affiliation

Animal Health Research Institute, El-Dokki, Giza

Email

-

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

16572

Issue Date

2005-04-01

Receive Date

2005-01-01

Publish Date

2005-04-01

Page Start

115

Page End

134

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 3_Issue 1_Pages 115-134.pdf

PDF . 817.4kB

Link

https://kvmj.journals.ekb.eg/article_112450.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=112450

Order

9

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

PHARMACOLOGICAL STUDY ON THE EFFECT OF DICLAZURIL AND FLAVOMYCIN ON THE IMMUNE RESPONSE IN CHICKENS

Details

Type

Article

Created At

22 Jan 2023