Beta
ManageSearchChatDiscover
112448

DISPOSITION KINETICS OF DIFLOXACIN IN NORMAL AND EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Veterinary Pharmacology, Toxicology and Forensic Medicine.

Abstract

The pharmacokinetic properties of difloxacin were investigated follo-wing intravenous, intramuscular and oral administration of 10 mg/kg body weight, in non-infected and experimentally mycoplasma infected chickens. Serum concentrations of difloxacin were assayed microbial-ogically after intravenous, intramuscular and oral administrations. difl-oxacin residues were detected in chicken tissues following repeated oral administrations in non-infected and infected chickens.
Following a single intravenous injection, the serum difloxacin level was best approximated to follow a two-compartment open model. The elimination half-life (t0.5b) was 4.58 + 0.008 h. The volume of distri-bution at steady-state (Vdss) was 2.12 + 0.07 L/kg and the mean resid-ence time (MRT) was 3.91 + 0.07 h.
Following a single oral administration of 10 mg/kg b.wt difloxacin,the recorded results revealed that serum level of difloxacin was higher in infected chickens than non infected chickens. Serum concentrations peaked one hour post-drug administration with half lifes of absorption (t0.5ab) of 0.48 + 0.02 and 0.37 + 0.02 hour in non infected and myc-oplasma infected chickens, respectively. The extent of serum protein binding of difloxacin in non-infected chickens was 15.44 + 1.24%. Systemic bioavailability after oral and intramuscular administration of difloxacininnon-infectedchickenswas75.87and 93.03%,respectively.
Following oral and intramuscular administration of 10 mg difloxacin / kg b.wt once daily for 5 consecutive days in infected and non infected chic-kens, the drug could be detected in all tested tissue up to 48 hours after last oral and intramuscular dose in non infected and infected chickens.

DOI

10.21608/kvmj.2005.112448

Keywords

difloxacin, chickens, Mycoplasma Gallisepticum

Authors

First Name

M.I.

Last Name

Abdel Aziz

MiddleName

-

Affiliation

Pharmacology Department, Fac. of Vet. Med. Tanta Univ. (Kafr El-Sheikh)

Email

-

City

-

Orcid

-

First Name

K.A.

Last Name

El Shazly

MiddleName

-

Affiliation

Pharmacology Department, Fac. of Vet. Med. Tanta Univ. (Kafr El-Sheikh)

Email

-

City

-

Orcid

-

First Name

W.M.

Last Name

El-Gazar

MiddleName

-

Affiliation

Pharmacology Department, Fac. of Vet. Med. Tanta Univ. (Kafr El-Sheikh)

Email

-

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

16572

Issue Date

2005-04-01

Receive Date

2005-01-01

Publish Date

2005-04-01

Page Start

97

Page End

113

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 3_Issue 1_Pages 97-113.pdf

PDF . 595.9kB

Link

https://kvmj.journals.ekb.eg/article_112448.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=112448

Order

8

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

DISPOSITION KINETICS OF DIFLOXACIN IN NORMAL AND EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM

Details

Type

Article

Created At

22 Jan 2023