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112435

TAURINE AND CAFFEINE-CONTAINING ENERGY DRINKS: LUMINAL PRESENCE OF TAURINE REDUCES BACLOFEN INTESTINAL ABSORPTION IN RATS

Article

Last updated: 04 Jan 2025

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Tags

Veterinary Pharmacology, Toxicology and Forensic Medicine.

Abstract

The absorption of baclofen (BAC), a centrally acting antispastic agent with γ-amino acid structure as well as the influence of taurine (TAU) and caffeine (CAFF) on baclofen permeability was investigated by in-situ single-pass rat intestinal perfusion. Taurine is known to be transp-ortedbyβ-aminoacidcarrier,atransporterthat ispresumed to be shared by baclofen in its intestinal absorption. The aim of this study was to characterize the intestinal transport properties of baclofen in three different intestinal segments and to demonstrate the influence of co-administration of taurine as a competitive inhibitor of active baclofen absorption. Jejunum, ileum and colon of male White Wistar rats (n=4) were perfused simultaneously. Baclofen concentration was 0.1 mM, a concentration,atwhichbaclofentransportisnot yet saturated.Following 30 minutes perfusion with pure baclofen in tyrode solution, 400mg/dl taurine (32 mmol/l), resp. 30 mg/dl caffeine (0.62 mmol/l) were added solely as well as in combination to the perfusion solution and the perf-usion was continued in the same animal up to 90 minutes. Taurine and caffeine concentrations corresponded to those usually used in energy drinks. Additionally, baclofen permeability was directly studied using a typical energy drink (ED)Red Bull® instead of tyode.The perfusates were collected and baclofen concentrations were quantified by HPLC. The intestinal permeabilities (Peff) were determined on the basis of the differences between the inlet and outlet concentrations. Results from in-situ intestinal perfusions in jejunum showed that Peff values are approximately reduced to 19.5% following addition of taurine, 10.4% by addition of taurine plus caffeine. The energy drink reduced baclofen permeability to 13.9%. The effect of taurine and caffeine in ileum and colon was similar to those found in jejunum.

DOI

10.21608/kvmj.2004.112435

Keywords

Taurine Reduces, Baclofen, Intestinal absorption, Rats

Authors

First Name

C.

Last Name

Leisen

MiddleName

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Affiliation

Department of Pharmaceutical Chemistry, School of Pharmacy, Martin-Luther-University Halle-Wittenberg, Germany

Email

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City

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Orcid

-

First Name

A.

Last Name

Hanafy

MiddleName

-

Affiliation

Department of Pharmacology and Forensic Medicine, Faculty of Vet. Med., Kafr El-Sheikh, Tanta University, Egypt

Email

-

City

-

Orcid

-

First Name

H.

Last Name

Spahn-Langguth

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, School of Pharmacy, Martin-Luther-University Halle-Wittenberg, Germany

Email

-

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

16569

Issue Date

2004-10-01

Receive Date

2004-07-14

Publish Date

2004-10-01

Page Start

179

Page End

195

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 2_Issue 2_Pages 179-195.pdf

PDF . 835.0kB

Link

https://kvmj.journals.ekb.eg/article_112435.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=112435

Order

11

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

TAURINE AND CAFFEINE-CONTAINING ENERGY DRINKS: LUMINAL PRESENCE OF TAURINE REDUCES BACLOFEN INTESTINAL ABSORPTION IN RATS

Details

Type

Article

Created At

22 Jan 2023