Beta
ManageSearchChatDiscover
111146

COMPARATIVE STUDY ON DIFFERENT METHODS OF EXPERIMENTAL ARTHRITIS INDUCTION IN EQUINE

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Veterinary Surgery and Theriogenology.

Abstract

Animal models for osteoarthritis (OA) are essential for studying the disease process and evaluating different therapeutic protocols. To date, no ideal OA animal model has been described. This study is a trial to find an equine osteoarthritic model that mimics the naturally occurring one in the horse. The study utilized 15 donkeys, divided into 3 equal groups (n=5). The radio carpal joint of the right forelimb of donkeys were injected with 25mg monoiodoacetate (group A), 50mg allogenous cartilage particles (group B), or normal saline (group C) over a period of 70 days. Lameness score, carpal circumference, joint flexion angel, Synovial fluid analysis (total protein and WBC count), were measured weekly over 70 days. There were marked significant change in the clinical signs and synovial fluid analysis between group A and B compared to group C. ACP and MIA in the donkey are suitable models to be investigated as a viable and less expensive alternative for an equine OA model. Injection of ACP may be a good model to study the disease process of osteoarthritis as well as evaluation of diseases modifying osteoarthritis drugs. However, injection on MIA is useful to study the pain effect and acute stage of arthritis as well as evaluation of Non-steroidal anti-inflammatory drugs.

DOI

10.21608/kvmj.2013.111146

Keywords

donkey, Lameness, osteoarthritis, cartilage, synovial membrane

Authors

First Name

Ahmed MA.

Last Name

Elmesiry

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Kafrelsheikh University

Email

-

City

-

Orcid

-

First Name

Ali A.

Last Name

Mansour

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Kafrelsheikh University

Email

-

City

-

Orcid

-

First Name

Magdi A.

Last Name

Seleim

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Kafrelsheikh University

Email

-

City

-

Orcid

-

Volume

11

Article Issue

1

Related Issue

16457

Issue Date

2013-04-01

Receive Date

2013-01-01

Publish Date

2013-04-01

Page Start

113

Page End

132

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 11_Issue 1_Pages 113-132.pdf

PDF . 790.6kB

Link

https://kvmj.journals.ekb.eg/article_111146.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=111146

Order

7

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

COMPARATIVE STUDY ON DIFFERENT METHODS OF EXPERIMENTAL ARTHRITIS INDUCTION IN EQUINE

Details

Type

Article

Created At

22 Jan 2023