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110136

THE EFFECT OF TILMICOSIN AND APRAMYCIN ALONE OR TOGETHER IN TREATMENT OF EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM ONLY OR WITH ESCHERICHIA COLI

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Veterinary Pharmacology, Toxicology and Forensic Medicine.

Abstract

Mycoplasmosis remains one of the most expensive and common diseases facingpoultry industry. The presence of Mycoplasma gallisepticum (MG) predisposes birds to other infections as Escherichia coli which together causes mortality, and sub-optimal performance. Therefore, this study was carried out to evaluate the efficacy of tilmicosin, apramycin and both drugs together on experimentally infected chicken with local field isolates of MG only or with E. coli as CRD and CCRD treatments. The present investigation clarified that infected groups treated with both tilmicosin and apramycin showed additive or synergistic interaction between them, which in turn confirmed the safety use of this combination therapy. The use of the recommended therapeutic dose of tilmicosin (1ml/L) or apramycin (0.5gm/L) alone or in combination for 5 successive days after appearance of the clinical signs are of considerable value in the treatment of MG infection in broiler chickens as antimycoplasmal drugs through displayed valuable improvement in clinical symptoms, survival rate, lesion scoring and termination of infection by the mycoplasmacidal effect of both drugs. The results also indicated that combined tilmicosin-apramycin therapy as antimicrobial drugs gives relatively stable results in the treatment of CCRD in chickens with a superior activity and efficacy than apramycin or tilmicosin alone followed by apramycin in reducing the severity of lesion, mortality rate, E. coli count and improve the general activity of chickens, so it can be used as alternative strategy that may contribute to the treatment programs of CCRD. Co-infected group treated with tilmicosin showed less improvement than other MG and E. coli infected treated groupsthis returned to its restricted effect on E. coli infection.

DOI

10.21608/kvmj.2014.110136

Keywords

Mycoplasmosis, tilmicosin, apramycin

Authors

First Name

M. I.

Last Name

Abd El Aziz

MiddleName

-

Affiliation

Pharmacology Department, Fac. Vet. Med. Kafrelsheikh University

Email

-

City

-

Orcid

-

First Name

K. A.

Last Name

El Shazly

MiddleName

-

Affiliation

Pharmacology Department, Fac. Vet. Med. Kafrelsheikh University

Email

-

City

-

Orcid

-

First Name

Mona, A.

Last Name

El Kahky

MiddleName

-

Affiliation

Animal Health Research Institute, provincial lab. Tanta.

Email

-

City

-

Orcid

-

First Name

Eman, M. E.

Last Name

El Sherbeney

MiddleName

-

Affiliation

Animal Health Research Institute, provincial lab. Tanta.

Email

-

City

-

Orcid

-

Volume

12

Article Issue

1

Related Issue

16456

Issue Date

2014-04-01

Receive Date

2014-01-01

Publish Date

2014-04-01

Page Start

139

Page End

178

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 12_Issue 1_Pages 139-178.pdf

PDF . 1.1MB

Link

https://kvmj.journals.ekb.eg/article_110136.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=110136

Order

9

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

THE EFFECT OF TILMICOSIN AND APRAMYCIN ALONE OR TOGETHER IN TREATMENT OF EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM ONLY OR WITH ESCHERICHIA COLI

Details

Type

Article

Created At

22 Jan 2023