Beta
ManageSearchChatDiscover
109857

THE POTENTIAL PROTECTIVE EFFECT OF LICORICE ON AFLATOXIN INDUCED HEPATOTOXICITY IN RATS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Veterinary Anatomy, Histology and Physiology “Veterinary Academic Studies".

Abstract

Aflatoxins, toxic metabolic by-products produced by Aspergillus flavus and A. parasiticus, are unavoidable food contaminant and reducing their toxicity in animals is of great interest. The potential of licorice which exhibits antioxidant and anti-inflammatory properties was evaluated for alleviating the AFB1-induced (Aflatoxin B1) hepatotoxicity in rat. Four experimental groups were used, each comprising 5 rats; control group (G1), licorice-received group (G2) (300mg/kg b.w intragastric daily for 7 days), AFB1-treated group (G3) (5 mg/kg b.w. one dose intrapretonial), and a group given licorice 7 days before AFB1 intoxication (G4) 24 hours later, the animals sacrificed. The activities of Alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) were measured in rat serum as well as histopathological examination of liver. Results revealed the following: AFB1 significantly elevated the serum ALT, AST and the liver showed diffuse  necrosis, bile duct hyperplasia, congestion of the central vein and portal mononuclear cells infiltrations. Rats received licorice before AFB1, showed a significant amelioration in serum enzymes and improvement in liver tissues architecture. In conclusion, licorice was found to be safe and successful agent counteracting the toxicity induced by AFB1 in the liver of rat.

DOI

10.21608/kvmj.2014.109857

Keywords

Aflatoxin, licorice, Rats, ALT, AST, Liver, histopathology

Authors

First Name

Nagwan

Last Name

El- Habashi

MiddleName

-

Affiliation

Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University

Email

-

City

-

Orcid

-

First Name

Dalia

Last Name

Daoud

MiddleName

-

Affiliation

Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

Abd-Elaziz

MiddleName

-

Affiliation

Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Sawak

MiddleName

Ali

Affiliation

Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University

Email

-

City

-

Orcid

-

Volume

12

Article Issue

1

Related Issue

16456

Issue Date

2014-04-01

Receive Date

2014-01-01

Publish Date

2014-04-01

Page Start

25

Page End

41

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 12_Issue 1_Pages 25-41.pdf

PDF . 1.0MB

Link

https://kvmj.journals.ekb.eg/article_109857.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=109857

Order

2

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

THE POTENTIAL PROTECTIVE EFFECT OF LICORICE ON AFLATOXIN INDUCED HEPATOTOXICITY IN RATS

Details

Type

Article

Created At

22 Jan 2023