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110156

ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Veterinary Anatomy, Histology and Physiology “Veterinary Academic Studies".

Abstract

Hepatitis C virus (HCV) infection is a major health problem. Egypt has the highest prevalence worldwide. Currently, combined pegylated interferon and ribavirin therapy is the standard treatment but the outcome is not satisfactory. The present study aimed To assess the possible association of serum IL-10 level, SOD activity in erythrocyte lysate and plasma MDA level and response to combined interferon α-2a and ribavirin therapy in chronic HCV infection.
In (Group < /em> I) who were not responded to pegylated interferon and rebavirin combination therapy  we found the level of serum IL-10 and plasma MDA still high while antioxidant enzyme SOD activity reduced. While in (Group II) who responded to pegylated interferon and rebavirin combination therapy a circulating serum IL-10 and plasma MDA levels reduced but erythrocyte antioxidant enzyme SOD activity increased. 

DOI

10.21608/kvmj.2014.110156

Keywords

Chronic hepatitis C, IL-10, Pegylated Interferon

Authors

First Name

S. Z.

Last Name

Abd al aziz

MiddleName

-

Affiliation

Department of chemistry, Faculty of Science, Beni-Suef University

Email

-

City

-

Orcid

-

First Name

Hannan A.

Last Name

Soliman

MiddleName

-

Affiliation

Department of chemistry, Faculty of Science, Beni-Suef University

Email

-

City

-

Orcid

-

First Name

S. R.,

Last Name

Abdel raheim

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Medicine, Minia University, Egypt

Email

-

City

-

Orcid

-

First Name

A. M.

Last Name

Okasha

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Medicine, Minia University, Egypt

Email

-

City

-

Orcid

-

First Name

Nilly Helmy

Last Name

Abdalla

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Beni-Suef University

Email

-

City

-

Orcid

-

Volume

12

Article Issue

2

Related Issue

16455

Issue Date

2014-10-01

Receive Date

2014-07-01

Publish Date

2014-10-01

Page Start

129

Page End

151

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 12_Issue 2_Pages 129-151.pdf

PDF . 839.1kB

Link

https://kvmj.journals.ekb.eg/article_110156.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=110156

Order

8

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

ASSESSMENT OF SERUM INTERLEUKIN-10 LEVEL IN CHRONIC HEPATITIS C PATIENTS TREATED WITH PEGYLATED INTERFERON AND RIBAVIRIN

Details

Type

Article

Created At

22 Jan 2023