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110147

A STUDY ON THE IMMUNOMODULATING EFFECT OF GENTAMICIN ON BROILERS VACCINATED WITH NEWCASTLE DISEASE VIRUS

Article

Last updated: 25 Dec 2024

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Subjects

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Tags

Veterinary Pharmacology, Toxicology and Forensic Medicine.

Abstract

The aim of the present work is to study immunomodulating effect of gentamicin on broiler chickens vaccinated against Newcastle virus at 18 days and  challenged with a  virulent strain of ND at the 30th day of age. Three groups of one day old Hubbard chicks each of 30 birds were used in this study. Chicks of the 1st group received 10 mg gentamicin /kg b. wt and those of the 2nd group were given 20mg gentamicin /kg b. wt . All the birds of the two groups were injected S/C at 14th,15th and 16th days of age .Birds of the 3rd group were used as control non treated group. Blood samples were collected from  ten birds of each group at 25 and 35 days of the experiment. Number of dead birds were recorded daily, body weight and feed conversion were estimated weekly till the end of the experiment (at 45 day). Also, the lymphoid organs (thymus, bursa and spleen) were carefully separated & weighed and each organ relative weight was determined. It was observed that administration of gentamicin (10mg/kg)did not  induce any  significant changes of blood cell count and relative weights of the lymphoid organs. Additionally, it decreased the phagocytic activity, serum total protein and albumin upto 1 week post vaccination. On the other hand, administration of gentamicin (20mg/kg) decrease the blood cell count, phagocytic activity and the relative weights  of the bursa. Both doses of gentamicin provoked a significant decrease in serum globulin, HI titer and protection %.

DOI

10.21608/kvmj.2014.110147

Keywords

immunomodulating effect, gentamicin, Broiler chickens, Newcastle virus

Authors

First Name

M.F.

Last Name

El Dakroury

MiddleName

-

Affiliation

Department of Pharmacology, Animal Health Research Institute, provisional lab Kafer El-Sheikh

Email

-

City

-

Orcid

-

First Name

M.M.

Last Name

Elseify

MiddleName

-

Affiliation

Department of Microbiology. Animal Health Research Institute, provisional lab Kafer El-Sheikh

Email

-

City

-

Orcid

-

Volume

12

Article Issue

2

Related Issue

16455

Issue Date

2014-10-01

Receive Date

2014-07-01

Publish Date

2014-10-01

Page Start

63

Page End

77

Print ISSN

1687-1456

Online ISSN

2682-2954

Article File

KVMJ_Volume 12_Issue 2_Pages 63-77.pdf

PDF . 647.0kB

Link

https://kvmj.journals.ekb.eg/article_110147.html

Detail API

https://kvmj.journals.ekb.eg/service?article_code=110147

Order

4

Type

Original Article

Type Code

1,064

Publication Type

Journal

Publication Title

Kafrelsheikh Veterinary Medical Journal

Publication Link

https://kvmj.journals.ekb.eg/

MainTitle

A STUDY ON THE IMMUNOMODULATING EFFECT OF GENTAMICIN ON BROILERS VACCINATED WITH NEWCASTLE DISEASE VIRUS

Details

Type

Article

Created At

22 Jan 2023