Convincing seroimmunological studies were conducted to explore the
influence of sheep pox vaccine on the immune response to pneumo-4
vaccine in vaccinated sheep, when it is administrated before, after and
simultaneously. The experiment was conducted on eighteen susceptible
sheep divided into 6 equal groups. Groups 1 and 5 were vaccinated
with pneumo-4 vaccine and sheep pox vaccine respectively regarded
as control vaccinated groups. Sheep pox vaccine was administered
simultaneously with pneumo-4 in Group (2), before and after pneumo-
4 vaccine in groups (3 and 4) respectively. The sixth group being left
as a non-vaccinated control. The developed antibodies against
different antigens incorporated in the used vaccines were monitored
by using both serum neutralization test (SNT) and ELISA. The results
showed that when sheep pox was administered one-week before
vaccination with pneumo-4, the highest antibody titres were developed
followed by these induced by simultaneous vaccination in group (2).
So, the result explores the immunopotentiating effect of sheep pox
vaccine on the immune response of sheep to pneumo-4 vaccine
specially when it is administered one week before the other vaccine.