Background: Enuresis is a common presentation among school children and the most common type is primary monosymptomatic nocturnal enuresis (PMNE). Children suffering from enuresis have at least one psychological or psychiatric problem as attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder ODD. Objective: This study aims at evaluating the frequency and association between (PMNE) and disruptive behavioral disorders in children and young adolescents. Methods: A case-control study conducted at Family medicine and child psychiatry clinics at the Center of Social and Preventive care, 110 children diagnosed with PMNE were assessed for disruptive behavioral disorders using Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) and Conners Parent Rating Scale-48 items (CPRS-48). Findings were compared with a matched group of 110 children without enuresis. Children and parents were interviewed and diagnosis was confirmed by a child psychiatrist. Results: The frequency of disruptive behavioral disorders was higher among cases. The frequency of ADHD, ODD, and conduct disorder in the cases group (57%, 36% and 30 % respectively) were significantly higher compared to control group (23%, 11.8% and 8.2 % respectively). ADHD-I (predominantly inattentive type) showed the highest prevalence among ADHD subtypes 31(28%). The odds of children having ADHD were 4.5 significantly higher for children with PMNE [OR: 4.56, 95% CI (2.54-8.18)]. Comparing cases and controls the odds ratio for conduct disorder and ODD are [OR: 4.8, 95% CI (2.17-10.65)] [OR: 4.1, 95% CI (2.04-8.24)] respectively. Conclusion: A significant association is present between PMNE and disruptive behavioral disorders in children and young adolescents.