A total number of 210 unsexed 7 days old Hubbard broiler chicks were used in this study to assessment of using cake by-products (CBP) as an alternative energy source in broiler diets on growth performance, carcass characteristics and economic efficiency. Chicks were divided randomly into seven equal treatments (30 birds each) contained 0%, 15%, 30%, 45%, 60%, 75% and 100% replacing yellow corn with CBP. Results of this experiment showed that, chicks' performance including live body weight (LBW), daily weight gain (DWG), daily feed consumption (DFC) and feed conversion ratio (FCR) didn't significantly differ between treatments at different periods and overall period. Carcass traits were not significantly affected among treatments. Economic study indicated that 100% CBP treatment is the most profitable diet among experimental diets. In conclusion, cake by-products (CBP) can be used with broiler chicks' diets without any negative effect on bird performance, carcass traits and improved the relative economic efficiency.