The mid rib of date palm (MRP), dry tomato waste (TW) and dry prickly pear peels (PPP) are annually represents about 40% of agro-industrial and food processing byproducts in Egypt, and considered as environmental pollutants, so, urgency needs to safely and proper utilized especially those contains some valuable nutrients, hence, one hundred and fifty unsexed Hubberd broiler chicks were used to evaluate the possibility of supplementation of broiler diets by 5 % (starter) and 10% (grower) of MRP, TW or PPP with 200 mg/kg diet of PBP (PhytaBexPlus® as multienzyme preparation) supplementation in all supplemented diets except the negative control ones. Concerning treatments included NCon (un - supplemented control diet), PCon (Control diet+ PBP), MRP + PBP, PPP +PBP and TW + PBP. At 35 days old, PBP didn't significantly affect daily weight gain but increased feed consumption, plasma globulin, and ALT of chicks, and reduced plasma total protein, albumin and A/G ratio. The MRP reduced WG and FC of chicks compared with TW or PPP. Feed conversion ratio didn't significantly affect by either PBP or byproduct type. Carcass characteristics didn't significantly affect by treatments except gizzard percent. This study recommended that, it could be included PPP or TW in broiler diets by levels 5% of starter diet or 10% of grower diet without any negative effect on performance, carcass characteristics or plasma constituents of chicks. While MRP supplementation with the same range caused a drop in WG and FI with significant effect on some essential plasma constituents of chicks. The rate of 200 mg/Kg diet of PBP which recommended by product guide may be not sufficient to appear a visual affect on broiler performance