This study was conducted to study the effect of bacteria isolated, commercial enzymes and yeast culture as feed additives in rations of lactating Zaraibi Goats on nutrients digestibility, nutritive values, milk yield, milk composition, blood metabolites and economical return. Twenty four lactating Zaraibi Goats  averaged 42.20 ± 1.28 kg live body weight (LBW) at the 3^rd and 4^th parities were assigned after parturition to four similar groups (6animals each).  Animals were fed concentrate feed mixture and berseem at the rate of 60: 40 % on DM basis, respectively (as a basal ration). The first group (G1) fed a basal ration without feed additives, the second group(G2) fed the basal ration with 10 g/doe/day of bacteria isolated, the third group (G3) fed a basal ration plus 10 g/doe/day of fibrozyme and   the fourth group (G4) fed a basal ration with 10 g/doe/day of yeast culture (Saccharomyces Cerevisiae 1×10⁹ CFU/g) during 15 weeks of lactation period. Results indicated that rations of G2, G3 and G4 significantly (P<0.05) increased DM, OM and CF digestibility in comparison with ration of G1. The second group (G2) was significantly (P<0.05) increased EE digestibility as compared to control and other additives rations. Group (G4) was significantly (P<0.05) higher in CP digestibility and DCP% than other groups (G1, G2 and G3). Animals fed rations supplemented with isolated bacteria or yeast culture had significantly (P<0.05) higher in TDN % than those in others. Milk yield and fat corrected milk (4% FCM) increased by (20.46 % and 21.19 %) for G3, (18.06% and 17.34 %) for G4 and (14.28 % and 16.46 %) for G2, respectively, compared to the control group. Milk content of fat, Protein, SNF and TS were significantly (P<0.05)   higher in Goats fed rations G2 and G3 comparing with those in G1 and G4. Lactose was significantly (P<0.05) higher for G3. Feed efficiency values as kg 4% FCM per one kg DM, TDN or DCP were higher with G2, G3 and G4 rations than that of G1 ration. Blood parameters were in the normal physiological ranges with no adverse effect on dairy Goats health. Animals of G4 had a significantly (P<0.05) higher in concentration of plasma protein fraction (total protein, Albumin and globulin) compared with the others groups .The fourth group (G4) had significantly (P<0.05) higher for AST (IU/L) than G2. While, ALT value (IU/L) for G3 was significantly (P<0.05) higher than that in control ration (G1).   Economic efficiency value was the highest with G2 followed by G4 while, G3 had the lowest value as compared to the control ration G1. In general, results of the current study indicated that using bacteria isolated, fibrozyme and yeast culture as feed additives in lactating Goats rations plays important role in improving  nutrients digestibility, feeding values, milk yield prolonged the persistency period and maintained body weight change. Economically, it is clear that bacteria isolated supplementation is superior to the other treatment groups and the cheapest price