An this study, mannan-oligosaccharide (MOS) and vitamin E (Dl-α-tocopheryl acetate) were used as feed supplements to ameliorate the deleterious effect of ochratoxin-A (OTA) on laying hens productive performance and some blood constituents. A total of 180 Inshas hens, 28 weeks of age were randomly distributed according to diet supplementation into six groups (30 hens, each in 3 replicates) as follow. T1: was fed a hen diet without any supplementation (control); T2: was fed the control diet supplemented with 1 g MOS / kg diet; T3: was fed the control diet supplemented with 150 mg vit. E / kg diet; T4: was fed the control diet contaminated with 1000 ppb of OTA. While, T5: was fed the control diet contaminated with 1000 ppb OTA and supplemented with 1 g MOS / kg diet; and T6 was fed the control diet contaminated with 1000 ppb OTA and supplemented with 150 mg vit. E / kg diet. Results showed that feed contaminated with OTA at 1000 ppb (T4) significantly decreased egg production percentage and feed consumption compared with the control group (but feed conversion was not affected). On the other hand, addition of either MOS or vit. E can ameliorate the toxic effects of OTA on productive performance and meat quality of hens.