Eighteen lactating Zaraibi goats were designed experiment to determine the effects of three different rations (isocaloric and isonitrogenic) supplemented with different levels of propylene glycol (PG) on goats welfare during critical transition stages. The three rations formed as PG0, PG1 and PG2 which alternative of 0, 10 and 20% of concentrate feed mixture (CFM), respectively. These rations were prepared and continued feeding to the three dairy nanny goat groups (n=6 each group) from flushing up to 21st weeks of lactation. The body weight, measurements post-parturition, milk production such as suckling and milking amount, feed consumption and blood samples were evaluated. Then, economical efficiency was assayed for selling milk yield. Experimental results indicated that both dietary groups included PG1 and PG2 showed higher (P<0.05) body weight through transition periods. Supplementation of PG in ration as 10 or 20% could be improved measurements post-parturition more than goat group untreated with PG. The milk production such as suckling and lactating of the PG groups were significantly higher than that of the control group (P<0.05). The PG1 and PG2 goats had lower (P<0.05) effect on dry matter intake (DMI) than PG0 during transition periods. The effect of different levels of PG containing rations on the main blood serum of goat such as glucose, non-esterified fatty acids (NEFA), β-hydroxyl butyric acid (βHBA) and blood urea nitrogen (BUN) were varied through pre / post-partum. Hence, concentration of serum glucose in the PG groups were significantly higher than that of the control group (P<0.05) through pre / post-partum. Conversely, the concentrations of NEFA, βHBA and BUN in the PG groups were lower than those of the control group (P<0.05) through pre / post-partum. In addition, commercial milk amount, selling price of milk and total price was lower in PG1 and PG2 groups than PG0 thus, PG  showed higher economical value than control goats. It can be concluded that inclusion of PG instead of 10 or 20% of CFM in the dairy nanny goats' diet lead to economic benefit positively such as body weight, reproductive performance post-partum, milk production, feed consumption and blood metabolic. Generally, supplementation with PG might have been attained among dairy goats on lower planes of nutrition or otherwise less optimally managed and also prevents any negative risk on goats healthy during critical transition periods.