This work aimed to study the influence of replacement 15 or 30% of soybean meal protein by either lentil screening by-products protein (LSBP) or chickpea screening by-products protein (CSBP) on performance, nutrients digestibility, plasma parameters, carcass measurements and economic profitability of growing rabbits. Sixty New Zealand White (NZW) growing rabbits, six weeks of age, were divided to five experimental groups. Each group included four replicates (three rabbits each) as follow: control group fed basal diet without LSBP or CSBP; the 2nd, 3th, 4th and 5th groups of rabbits fed 15% LSBP, 30% LSBP, 15% CSBP and 30% CSBP diets, respectively. Results showed that LSBP has lower DM, OM and EE contents than CSBP. Meanwhile, LSBP has higher CP, CF, ash% and GE (kcal/kg) contents compared to CSBP. LSBP was higher in arginine, threonine, isoleucine, and lysine. Meantime, CSBP had higher contents in leucine, methionine and phenylalanine as predominant essential amino acids. Inclusion of LSBP and CSBP insignificantly improved FBW, BWG and FCR. However, average daily feed intake of rabbits fed 15% CSBP was higher (P<0.05) than those fed 30% CSBP. No significant differences were observed in all nutrients digestibility (DM, OM, CP, EE and NFE) and nutritive values expressed as DCP%, TDN% and DE Kcal/kg between groups of rabbits fed LSBP and CSBP diets and those fed the control diet. Meanwhile, group of rabbits fed 30% LSBP had higher (P<0.05) CP digestibility. Conversely, group of rabbits fed 30% CSBP recorded the lowest (P<0.05) CP digestibility. Significant higher (P<0.05) values of plasma total protein and albumin concentrations were recorded for rabbits fed diets contained 30% LSBP, 15 or 30% CSBP than the control group. Moreover, there were insignificant differences in globulin and uric acid among all the experimental groups. Regarding liver functions (AST and ALT), there was a significant decrease (P<0.05) in AST levels with rabbits fed 30% LSBP and 15 or 30% CSBP compared to the control group. No significant differences in most carcass measurements were found between rabbits fed different levels of LSBP and CSBP diets and those fed the control diet except heart, kidneys weights and total edible parts %. The inclusion of LSBP at a level of 15% significantly decreased (P<0.05) total edible parts % compared with the inclusion of 30% CSBP and the control group. The net revenue improved by 4.16, 7.75, 3.43 and 9.52% for 15% LSBP, 30% LSBP, 15% CSBP and 30% CSBP, respectively. The best net revenue and economical efficiency were recorded by 30% CSBP diet followed by 30%LSBP, 15%LSBP, 15% CSBP diets and the lowest one was the control group. In conclusion, lentil or chickpea screening by-products protein could be used up to 30% substitution level for soybean meal protein without any detrimental effects on performance, nutrient digestibility, plasma parameters and carcass measurements of growing rabbits.