An experiment was undertaken to study the impact of commercial β-glucan on growth performance, feed utilization and immunomodulatory effects of Nile tilapia fingerlings. Four isocaloric and isonitrogenous diets were formulatedwith three levels of β-glucan (0, 0.6, 1.2 and 1.8%) and fed to the fish for 84 days. The tested diets were applied in 12 fiberglass tanks (80 x 60 x 60 cm) each was supplied arbitrarily with 20 Nile tilapia fingerlings with anmoderate starting body weight of 10 ± 0.20g. Generally, We found that adding β-glucan to the diet improve fish growth performance, feed conversion ratio, protein efficiency ratio and Apparent protein digestibility were enhanced for tilapia fingerlings compared to fish fed on the control diet. In terms of blood estimations no critical contrasts were identified in plasma albumin, total protein and total globulins of fish nourished on the tested diets. Conclusively, the results revealed that It is possible to include concentrations of 0.6 % of β-glucans in the diets for Nile tilapia, with detectable improvement on growth performance, feed utilization and survival.