This study was designed to evaluate the effects of dietary Nano-zinc (Nano-Zn) and Nano-selenium (Nano-Se) supplementation on growth performance, nutrients utilization, carcass parameters and blood plasma biochemical in growing rabbits. A total of 50, six-week-old New Zealand White (NZW) rabbits of about 815 g l.b.w. were randomly distributed into five equal groups. The control group was fed on a basal diet without any supplement; the second and third groups were fed the basal diet supplemented with 30 and 60 mg Nano-Zn/kg, respectively, while the fourth and fifth groups were fed the basal diet supplemented with 0.1 and 0.3 mg Nano-Se/kg, respectively during the experimental period (6-12 wks of age).The results revealed that rabbits fed diet supplemented with different Nano-Zn or Nano-Se levels had higher (P>0.05) live body weight at 12 wks than the control. Moreover, body weight gain, feed conversion ratio and protein efficiency ratio were insignificantly improved comparing with the control group at the whole experimental period (6-12 wks of age), rabbits fed diet supplemented with 60 mg Nano-Zn or 0.3 mg Nano-Se/kg recorded the higher value of different growth parameters. All studied nutrients digestibility and carcass traits were not significantly affected by dietary treatment. No significant differences were observed among experimental rabbit groups in studied plasma parameters by dietary Nano-Zn or Nano-Se supplementation as compared with the control group. Results generally showed that the best results in most studied traits were recorded for dietary 60 mg Nano-zinc or 0.3 mg Nano-selenium / kg diet of growing rabbits during experimental period. Therefore, the addition of 60 mg Nano-Zn or 0.3 mg Nano-Se/kg diet may be an alternative method to maximize the productivity of growing NZW rabbits without adverse effects during fattening period.