The objective of the experiment was to study the effect of adding germinated Moringa oleifera seeds (GMOS) on egg production performance, egg quality, some physiological parameters and reproduction performance of Japanese quail. A total number of 120 female and 60 male Japanese quail 60 day old were distributed randomly into four treatment groups, contained 3 replicates of 10 female and 5male per each. Dietary treatments were designed to contain 0.0 (control), 0.25, 0.50 and 0.75% germinated Moringa oleifera seed (GMOS) as growth promoters. Egg production parameter, feed consumption, feed conversion ratio, some physiological and reproduction parameters were determined. The results demonstrated that, 0.5% GMOS supplementation recorded the highest egg production percent and 0.25% recorded the highest average egg weight during different periods. Supplementation of GMOS at 0.25% and 0.5% levels had significantly (P≤0.05) higher WBCs, RBCs, Hb and Ht  than control treatment. Increasing GMOS level up to 0.75% recorded significantly (P ˂ 0.05) the highest total plasma protein and globulin. Total lipid, cholesterol and LDL significantly decreased, consequently, HDL increased significantly by GMOS supplementation. Diet supplemented with 0.5% GMOS presented significantly decreased (P≤0.05) liver enzymes and increased total antioxidant capacity and obtained the most excellent fertility, hatchability, dead and deformed percentage.In conclusion, germinated Moringa oleifera seeds supplementation at levels of 0.25,0.50 and 0.75% to Japanese quail diets improved egg production performance, egg quality, most hematological parameters, plasma component and reproductive performance.