The aim of the present study was to evaluate the effect of the partial replacement of clover hay (CH) by broccoli product with or without lipidol on growth performance of growing New Zealand White (NEW) rabbits. A total of sixty growing NZW rabbits at four weeks of age were randomly divided into six groups (10 rabbits each). Three different levels of broccoli by- product (0, 5 and 10%) of the diet were used, each level of broccoli by- product was fed without or with 0.05% lipidol. The results showed that there were no negative effect on live body weight and live body weight gain due to levels of broccoli by-product regardless of lipidol. Addition of  lipidol during the first period (4-9 weeks of age) improved both of live body weight and live body weight gain, while there was no significant difference between the values during the total experimental period (4-14 weeks of age). And the best treatment compared to the control (T1) was T5 (5% B+L), while there were no significant differences between the other treatment.Supplementation both broccoli by-product and lipidol significantly (P≤0.05) reduced fed intake but did not effect on feed conversion. There was a positive effect on all digestion coefficients of nutrients and nutritive valuesdue to level 10% of broccoli by-product regardless of lipidol treatment. T4(10%B) and T6 (10%B+L) resulted in maximum values for carcass dressing %. Both of the lipidol and broccoli by-product decreased EE% of rabbit meat. Addition of lipidol to the control and the other groups with broccoli showed an increase in length and slight increase in width of intestinal villi with normal epithelial lining and 5% replacement was the best. Almost all microbial counts decreased significantly (P≤ 0.05) due to broccoli replacement and lipidol supplementation. The best relative economical efficiency value was (133%) for T5(5%B+L). From the results of this experiment it could be concluded that addition of lipidol with replacement up to 10% of broccoli by-product in rabbit's diet, resulted in better performance, better economic efficiency and there were no adverse effect on physiological responses and carcass quality.