The present study aimed to investigate the effect of bacterial enzymes (ZAD) or effective microorganisms (EM) treated with rice straw on, digestibility, growth performance and economic efficiency of Ossimi sheep. Twenty four lambs (12 males and 12 females) were randomly divided into three groups where first group  fed on ration consisted of  (60% concentrate feed mixture (CFM) and 40% rice straw (RS) and served as control ration, and second group (R2) fed on (60% CFM and 40% RS+ZAD) and the third group (R3) fed on ration3 (60% CFM and 40% RS+EM).Results showed that both the ration included treated rice straw (R₂ and R₃) increased of CP, EE and Ash contents compared to non-treated rice straw ration (R₁). While CF content had the opposite trend. Control ration (R1₎ recorded the lowest of DM, OM, CP, EE, CF and NFE digestibilties compared to tested one which giving RS treated with ZAD or EM (R2 and R3). Also R2 and R3 had the highest values of TDN, DCP and DE compared to those of R1. Feed conversion of ratio was improved significantly (P<0.05) with ZAD or EM included rations (R2 and R3) compared with (R1). Blood parameters were positively affected by ZAD and EM ration. Growth performance (final weight, total gain and daily gain) were significant higher for both tested rations (R2&R3) than those of control one (R1). Also, economical efficiency of tested ration was markedly improved due to the inclusion treated rice straw in these rations.