This study was conducted in Animal Production Department Farm, Faculty of Agriculture, AinShamsUniversity, Shoubra El Kheima, Kalubeya Province, Egypt. This study was performed to compare the influence of different doses of enzymes (ZAD) in liquid form (ZL) on productive performance of Barki sheep. Twenty growing Barki sheep aged between 7-8 months with average body weight 43.4 kg BW were used in 75 days growth trial. Animals were divided into four treatments, T1; were fed basic diet, T2; were fed basic diet plus 1.5 ml orally dose of ZL/head/day.T3; were fed basic diet plus 2.5 ml orally dose of ZL/head/day.T4; were fed basic diet plus 4 ml orally dose of ZL/head/day. The results demonstrated that the Barki sheep received 4 ml ZL had better performance (P≤0.05) in total gain by 28.45%, ADG by 28.65% than the control group (without ZL). Results of In vitro gas production trial showed a significant (P≤0.05) positive effects of ZL on DMD, OMD and CPD. Also, ZL had a significant positive effects on all rumen parameters. Concerning productive performance results, in General, Barki sheep orally ZL dose showed significant improvement (P≤0.05) in the values of dry matter intake and dry matter conversion compared with control group. The mean values of plasma total protein, globulin and GPT concentrations had higher values (P≤0.05) for animals received 4 ml ZL than control group, while triglyceride and GOT levels in all groups remained relatively stable throughout the study. All blood parameters were being within normal range. In conclusion, use exogenous enzymes in liquid form to Barki sheep at dose (4 ml ZL) had positive and beneficial effects on enhance dry matter intake, dry matter conversion, average daily gain and total gain.