Abstract
Objective: To evaluate the effect of bioactive glass 45S5 in comparison to casein phosphopeptide amorphous calcium phosphate (CPP-ACP) for the treatment of post-orthodontic white spot lesions (WSLs).
Methods: Sixty patients with acquired post-orthodontic WSLs (score 2 ICDAS II) were recruited and randomly allocated to a double blind three-arm randomized controlled trial (n=20). Test group I (Bio-B45S5), test group II (Nov-B45S5), and the control group (CPP-ACP) received BiominF, Novamin, and Recaldent pastes respectively. Products were applied daily in-office during week 1, in addition to once per day home application for four weeks starting day 1. Standardized intraoral photographs and laser fluorescence DIAGNOdent were used for assessment at baseline (T0), 1 week (T1), 1 month (T2), 3,6,9, and 12 months (T3, T4, T5, T6 respectively).
Results: At T6, a statistically significant (p