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263136

SURGICAL CREATION OF CLEFT-LIKE PALATAL DEFECTS IN NEW ZEALAND RABBITS (A PILOT STUDY)

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Oral and maxillofacial surgery

Abstract

Introduction: Surgically Created cleft palate models in animals have solved most of the problems associated with congenital models. Recent studies have preferred the use of rats and rabbits as they are easy to handle and observe.
Objective:. The aim of this study was to surgically create a palatal defect in white New Zealand in rabbits. These defects were assessed radiographically and histologically to select the most reliable, reproducible and least invasive dimensions for creating a cleft-like palatal defect suitable to be used in future research to assess the regenerative capacity of new materials for cleft palate management.
Materials and Methods: A total of 7 rabbits were used in this pilot study; for defect optimization. Three different defect dimensions 7×2.5×1 mm³, 7×2.5×5 mm³ and 5×2.5×4 mm³ were created in the mid-palatal region. Maxillae were taken immediately after surgery and at 2 weeks interval for radiographic and histological analyses.
Results: 7×2.5×1 mm³ defects were shallow such that spontaneous healing of defects occurred. 7×2.5×5 mm³ defects with nasal mucosa removal showed death of all animals with severe injuries in vital structures. On the other hand, 5×2.5×4 mm³ defects with intact nasal mucosa showed preservation of vital structures without closure of the defect at 2 weeks.
Conclusions:. 5×2.5×4 mm³ defects have been found to be the largest yet most preservative dimensions for creating palatal defects in that region in rabbits without allowing spontaneous healing till 2 weeks.

DOI

10.21608/adjalexu.2021.69140.1174

Keywords

Palatal defects, cleft palate, Bone engineering, Rabbit model, Cleft animal model

Authors

First Name

Ayat

Last Name

Hamdy

MiddleName

-

Affiliation

Dentist at Ministry of Health, Alexandria, Egypt and Researcher at Tissue Engineering Labs,Alexandria,Egypt.

Email

ayat.hamdy.dent@alexu.edu.eg

City

-

Orcid

0000-00001-7983-737X

First Name

Manal

Last Name

Saad

MiddleName

-

Affiliation

Professor of Oral Biology,Faculty of Oral and Dental Medicine, Ahram Canadian University, Giza, Egypt and Researcher Tissue Engineering laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Email

saad_manal@hotmail.com

City

-

Orcid

0000-0002-3515-075X

First Name

Samir

Last Name

Nouh

MiddleName

Rashed

Affiliation

Veterinary Surgery, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt and Researcher at Tissue Engineering laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Email

nouhsamir@hotmail.com

City

-

Orcid

0000-0003-4023-1893

First Name

Adham

Last Name

ElAshwah

MiddleName

ahmed

Affiliation

Oral and maxillofacial surgery department, faculty of dentistry , Alexandria university , Alexandria ,Egypt

Email

adham1965@yahoo.com

City

alexandria

Orcid

000-0003-1764- 7655

First Name

Ahmed

Last Name

El Mahallawy

MiddleName

Salah

Affiliation

Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Email

ahmedelmahallawy@hotmail.com

City

-

Orcid

0000-0001-9610-4979

First Name

Samer

Last Name

Zaky

MiddleName

-

Affiliation

Center for Craniofacial Regeneration (CCR), University of Pittsburgh, Pennsylvania, USA

Email

somy77@yahoo.com

City

-

Orcid

0000-0001-5550-5450

First Name

Rania

Last Name

ElBackly

MiddleName

Mahmoud

Affiliation

Endodontics, Conservative Dentistry, Faculty of Dentistry, Alexandria University, Alexandria, Egypt and Researcher at Tissue Engineering laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Email

ranianoaman@gmail.com

City

alexandria

Orcid

0000-0003-3147-0032

Volume

47

Article Issue

3

Related Issue

37974

Issue Date

2022-12-01

Receive Date

2021-03-29

Publish Date

2022-12-01

Page Start

8

Page End

13

Print ISSN

1110-015X

Online ISSN

2536-9156

Article File

ADJALEXU_Volume 47_Issue 3_Pages 8-13.pdf

PDF . 702.4kB

Link

https://adjalexu.journals.ekb.eg/article_263136.html

Detail API

https://adjalexu.journals.ekb.eg/service?article_code=263136

Order

2

Type

Original Article

Type Code

1,057

Publication Type

Journal

Publication Title

Alexandria Dental Journal

Publication Link

https://adjalexu.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023