Introduction: Maxillary sinus membrane perforation is the most common intraoperative complications associated with the sinus lifting procedure. There are various sutureless techniques used in repairing of perforated sinus membrane including; collagen membrane, fibrin sealants, cyanoacrylate adhesives,amniotic membrane and fibringlue.
Objectives: The aim of this study was to compare between the use of amniotic membrane and fibrin glue in healing of perforated maxillary sinus in rabbits.
MATERIALS AND METHOD: This study was conducted on ten adult healthy male rabbits, with an average weight between 2-3 kgs. A split mouth design was implemented. In each rabbit, the right sinus membrane window was repaired by fibrin glue (group I), while the left sinus membrane window was repaired by amniotic membrane (group II).
Results: Histological results revealed that amniotic membrane enhanced faster reepithelialization of maxillary sinus membrane and bone healing where the amount of the newly formed bone observed in group II was greater than that of group I.  Histomorphometric analysis showed the increase in the bone surface area mean percentage in group II in comparison to group I.
Conclusion: According to the results of the present study, it was concluded that the amniotic membrane is effective in the repair of perforated sinus membrane with superior potentiality than fibrin glue especially in the early stage.