INTRODUCTION: Temporomandibular joint (TMJ) dislocation is an excessive forward movement of the condyle beyond the articular eminence with complete separation of the articular surfaces and fixation in that position. OBJECTIVES: the aim of the study was to compare clinically between the effect of autologous blood injection and platelet rich plasma injection in treatment of chronic recurrent temporomandibular joint dislocation through evaluation of mandibular range of motion. MATERIALS AND METHODS: Twenty patients with bilateral chronic recurrent condylar dislocation were included in this study. In group I 3mL autologous blood was injected. For group II 3ml of concentrated platelet rich plasma (PRP) was injected. Preoperative and postoperative assessment included a thorough history and physical examination to determine mandibular range of motion. RESULTS: Mandibular range of motion was significantly reduced post operatively in both groups, however on comparing the two groups there was statistically insignificant difference in mandibular range of motion. CONCLUSIONS: Both autologous blood and PRP injections are simple, low cost, and minimally invasive approaches which can be easily and safely injected. Both Autologous blood injection and PRP significantly decrease mandibular range of motion to normal range in patients with chronic recurrent TMJ dislocation.