INTRODUCTION: Debridement of the root canal system is essential for endodontic success. Traditional instruments alone cannot sufficiently clean root canals. There must be an effective delivery system. OBJECTIVES: was to compare the cleaning efficiency of XP-endo Finisher and the EndoActivator using the scanning electron microscope. MATERIALS AND METHODS Sixty human mandibular first premolars with single oval canals were used in this study. Teeth were instrumented using One-Shape file. Teeth were then randomly divided into three parallel groups (n=20) according to the agitation method used; Group I: XP-endo Finisher. Group II: EndoActivator. Group III: both XP-endo Finisher and EndoActivator. Teeth were sectioned longitudinally and assessed by the scanning electron microscope using the five-score debris and smear layer indices. Data were analyzed using Kruskal-Wallis, Friedman, and Dunn-Bonferroni tests. RESULTS: No significant differences were found between XP- endo Finisher and EndoActivator in debris and smear layer removal. In the middle segment, each of the XP-endo Finisher and EndoActivator revealed significantly lower debris scores than both together (P<0.05). In the coronal and apical segments the three groups equally cleaned debris (P>0.05). In smear layer removal, significant differences were found in both the coronal and apical segments between each one of the XP-endo Finisher and EndoActivator compared to both together (P<0.05). While in the middle segment, there were insignificant differences between the three groups in smear layer removal (P>0.05). The apical segment was more efficiently cleaned from debris and smear layer than the other segments in all groups. CONCLUSIONS: Irrigation of root canals using XP-endo Finisher and EndoActivator solely was more effective in the removal of debris and smear layer than both used together. The apical third was more efficiently cleaned from debris and smear layer than the other segments.