INTRODUCTION: The replacement of the natural teeth has been the aim of mankind since ancient time. That's why we use dental implant and its osseointegration should be enhanced. By using Cholecalciferol and Calcium on postmenopausal females. OBJECTIVES: The aim of the study was to evaluate the effect of combination of cholecalciferol and calcium on delayed dental implants healing for postmenopausal females. MATERIALS AND METHODS: A clinical and radiographical study was carried out on 14 postmenopausal female patients with age range from 40 to 60 years having missing maxillary anterior teeth. All the patients received the same implant system. The study group only received cholecalciferol and calcium for 8 months and the control group didn't receive thing. After placement all implants were evaluated clinically after 4 and 8 months (modified gingival index, papillary bleeding index, and degree of mobility) and radiographically after 4 and 8 months to evaluate marginal bone loss. RESULTS The study group showed an increase in bone density. Group I(study): was better with a mean of (120.8±39.53) pixel while Group II(control): showed a mean of (90.84±41.6) pixel the difference of the bone density between the two groups was statistically significant (p=0.008). CONCLUSIONS: The implant placement in postmenopausal female patients may be successful. Cholecalciferol and calcium has systemic effects on accelerating bone formation around titanium implants